Reaction: lactate + 2 NAD+ + 2 reduced ferredoxin [iron-sulfur] cluster = pyruvate + 2 NADH + 2 oxidized ferredoxin [iron-sulfur] cluster
Other name(s): electron bifurcating LDH/Etf complex
Systematic name: lactate:NAD+, ferredoxin oxidoreductase
Comments: The enzyme, isolated from the bacterium Acetobacterium woodii, uses flavin-based electron confurcation to drive endergonic lactate oxidation with NAD+ as oxidant at the expense of simultaneous exergonic electron flow from reduced ferredoxin to NAD+.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
1. Weghoff, M.C., Bertsch, J. and Muller, V. A novel mode of lactate metabolism in strictly anaerobic bacteria. Environ Microbiol 17 (2015) 670-677. [PMID: 24762045]