IUBMB Enzyme Nomenclature


Accepted name: cobalt-precorrin-6A reductase

Reaction: cobalt-precorrin-6B + NAD+ = cobalt-precorrin-6A + NADH + H+

For diagram of reaction click here.

Other name(s): cbiJ (gene name)

Systematic name: cobalt-precorrin-6B:NAD+ oxidoreductase

Comments: The enzyme catalyses a step in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis. The enzyme from the bacterium Bacillus megaterium has no activity with NADPH. The equivalent enzyme in the aerobic pathway is EC, precorrin-6A reductase.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Kim, W., Major, T.A. and Whitman, W.B. Role of the precorrin 6-X reductase gene in cobamide biosynthesis in Methanococcus maripaludis. Archaea 1 (2005) 375-384. [PMID: 16243778]

2. Moore, S.J., Lawrence, A.D., Biedendieck, R., Deery, E., Frank, S., Howard, M.J., Rigby, S.E. and Warren, M.J. Elucidation of the anaerobic pathway for the corrin component of cobalamin (vitamin B12). Proc. Natl. Acad. Sci. USA 110 (2013) 14906-14911. [PMID: 23922391]

[EC created 2014]

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