IUBMB Enzyme Nomenclature

EC 1.2.3.6

Accepted name: pyruvate oxidase (CoA-acetylating)

Reaction: pyruvate + CoA + O₂ = acetyl-CoA + CO₂ + H₂O₂

Systematic name: pyruvate:oxygen 2-oxidoreductase (CoA-acetylating)

Comments: A flavoprotein (FAD). May be identical with EC 1.2.7.1 pyruvate synthase.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 62213-57-4

References:

1. Reeves, R.E., Warren, L.G., Susskind, B. and Lo, H.-S. An energy-conserving pyruvate-to-acetate pathway in Entamoeba histolytica. Pyruvate synthase and a new acetate thiokinase. J. Biol. Chem. 252 (1977) 726-731. [PMID: 13076]

2. Takeuchi, T., Weinbach, E.C. and Diamond, L.S. Pyruvate oxidase (CoA acetylating) in Entamoeba histolytica. Biochem. Biophys. Res. Commun. 65 (1975) 591-596. [PMID: 167776]

[EC 1.2.3.6 created 1976]

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