Reaction: 2-oxoglutarate + CoA + NADP+ = succinyl-CoA + CO2 + NADPH
Other name(s): oxoglutarate dehydrogenase (NADP)
Systematic name: 2-oxoglutarate:NADP+ 2-oxidoreductase (CoA-succinylating)
Comments: The Euglena enzyme can also use NAD+ as acceptor, but more slowly.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 126469-85-0
References:
1. Inui, H., Miyatake, K., Nakano, Y. and Kitaoka, S. Occurrence of oxygen-sensitive, NADP+-dependent pyruvate dehydrogenase in mitochondria of Euglena gracilis. J. Biochem. (Tokyo) 96 (1984) 931-934. [PMID: 6438078]