Reaction: succinate semialdehyde + NAD+ + H2O = succinate + NADH + 2 H+
For diagram of reaction click here.
Other name(s): succinate semialdehyde dehydrogenase (NAD+); succinic semialdehyde dehydrogenase (NAD+); succinyl semialdehyde dehydrogenase (NAD+); succinate semialdehyde:NAD+ oxidoreductase
Systematic name: succinate-semialdehyde:NAD+ oxidoreductase
Comments: This enzyme participates in the degradation of glutamate and 4-aminobutyrate. It is similar to EC 220.127.116.11 [succinate-semialdehyde dehydrogenase (NADP+)], and EC 18.104.22.168 [succinate-semialdehyde dehydrogenase (NAD(P)+)], but is specific for NAD+.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9028-95-9
1. Albers, R.W. and Koval, G.J. Succinic semialdehyde dehydrogenase : purification and properties of the enzyme from monkey brain. Biochim. Biophys. Acta 52 (1961) 29-35. [PMID: 13860092]
2. Ryzlak, M.T. and Pietruszko, R. Human brain "high Km" aldehyde dehydrogenase: purification, characterization, and identification as NAD+-dependent succinic semialdehyde dehydrogenase. Arch. Biochem. Biophys. 266 (1988) 386-396. [PMID: 3190233]
3. Busch, K.B. and Fromm, H. Plant succinic semialdehyde dehydrogenase. Cloning, purification, localization in mitochondria, and regulation by adenine nucleotides. Plant Physiol. 121 (1999) 589-597. [PMID: 10517851]