IUBMB Enzyme Nomenclature


Accepted name: 4-methylphenol dehydrogenase (hydroxylating)

Reaction: 4-methylphenol + 2 acceptor + H2O = 4-hydroxybenzaldehyde + 2 reduced acceptor

Glossary: 4-methylphenol = 4-cresol = p-cresol

Other name(s): p-cresol-(acceptor) oxidoreductase (hydroxylating); p-cresol methylhydroxylase; 4-cresol dehydrogenase (hydroxylating)

Systematic name: 4-methylphenol:acceptor oxidoreductase (methyl-hydroxylating)

Comments: A flavocytochrome c (FAD). Phenazine methosulfate can act as acceptor. A quinone methide is probably formed as intermediate. The first hydroxylation forms 4-hydroxybenzyl alcohol; a second hydroxylation converts this into 4-hydroxybenzaldehyde.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, UM-BBD, CAS registry number: 66772-07-4


1. Hopper, D.J. and Taylor, D.G. The purification and properties of p-cresol-(acceptor) oxidoreductase (hydroxylating), a flavocytochrome from Pseudomonas putida. Biochem. J. 167 (1977) 155-162. [PMID: 588247]

2. McIntire, W., Edmondson, D.E. and Singer, T.P. 8α-O-Tyrosyl-FAD: a new form of covalently bound flavin from p-cresol methylhydroxylase. J. Biol. Chem. 255 (1980) 6553-6555. [PMID: 7391034]

[EC created 1983, modified 2001, modified 2011, modified 2015]

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