Reaction: (R)-reticuline + NADPH + H+ + O2 = salutaridine + NADP+ + 2 H2O
For diagram click here.
Other name(s): (R)-reticuline oxidase (C-C phenol-coupling)
Systematic name: (R)-reticuline,NADPH:oxygen oxidoreductase (C-C phenol-coupling)
Comments: A heme-thiolate enzyme (P-450). Forms the morphinan alkaloid salutaridine by intramolecular phenol oxidation of reticuline without the incorporation of oxygen into the product.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 149433-84-1
1. Gerady, R. and Zenk, M.H. Formation of salutaridine from (R)-reticuline by a membrane-bound cytochrome P-450 enzyme from Papaver somniferum. Phytochemistry 32 (1993) 79-86.