IUBMB Enzyme Nomenclature


Accepted name: deoxysarpagine hydroxylase

Reaction: 10-deoxysarpagine + NADPH + H+ + O2 = sarpagine + NADP+ + H2O

For diagram click here.

Other name(s): DOSH

Systematic name: 10-deoxysarpagine,NADPH:oxygen oxidoreductase (10-hydroxylating)

Comments: A heme-thiolate protein (P-450).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Yu, B., Ruppert, M. and Stöckigt, J. Deoxysarpagine hydroxylase — a novel enzyme closing a short side pathway of alkaloid biosynthesis in Rauvolfia. Bioorg. Med. Chem. 10 (2002) 2479-2483. [PMID: 12057637]

[EC created 2005]

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