Reaction: taxa-4(20),11-dien-5α-ol + NADPH + H+ + O2 = taxa-4(20),11-dien-5α,13α-diol + NADP+ + H2O
For diagram click here.
Systematic name: taxa-4(20),11-dien-5α-ol,NADPH:oxygen oxidoreductase (13α-hydroxylating)
Comments: This cytochrome-P450-dependent enzyme is involved in the biosynthesis of the diterpenoid antineoplastic drug taxol (paclitaxel).
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 399030-58-1
1. Wheeler, A.L., Long, R.M., Ketchum, R.E., Rithner, C.D., Williams, R.M. and Croteau, R. Taxol biosynthesis: differential transformations of taxadien-5α-ol and its acetate ester by cytochrome P450 hydroxylases from Taxus suspension cells. Arch. Biochem. Biophys. 390 (2001) 265-78. [PMID: 11396929]
2. Jennewein, S., Rithner, C.D., Williams, R.M. and Croteau, R.B. Taxol biosynthesis: taxane 13 α-hydroxylase is a cytochrome P450-dependent monooxygenase. Proc. Natl. Acad. Sci. U S A 98 (2001) 13595-135600. [PMID: 11707604]