Reaction: dihydrosanguinarine + NADPH + H+ + O2 = 10-hydroxydihydrosanguinarine + NADP+ + H2O
For diagram click here.
Other name(s): dihydrosanguinarine 10-hydroxylase
Systematic name: dihydrosanguinarine,NADPH:oxygen oxidoreductase (10-hydroxylating)
Comments: a heme-thiolate protein (P-450) involved in benzophenanthridine alkaloid synthesis in higher plants.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 144388-41-0
1. De-Eknamkul, W., Tanahashi, T. and Zenk, M.H. Enzymic 10-hydroxylation and 10-O-methylation of dihydrosanguinarine in dihydrochelirubine formation by Eschscholtzia. Phytochemistry 31 (1992) 2713-2717.