IUBMB Enzyme Nomenclature


Accepted name: protopine 6-monooxygenase

Reaction: protopine + NADPH + H+ + O2 = 6-hydroxyprotopine + NADP+ + H2O

For diagram click here.

Other name(s): protopine 6-hydroxylase

Systematic name: protopine,NADPH:oxygen oxidoreductase (6-hydroxylating)

Comments: a heme-thiolate protein (P-450) involved in benzophenanthridine alkaloid synthesis in higher plants.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 128561-60-4


1. Tanahashi, T. and Zenk, M.H. Elicitor induction and characterization of microsomal protopine-6-hydroxylase, the central enzyme in benzophenanthridine alkaloid biosynthesis. Phytochemistry 29 (1990) 1113-1122.

[EC created 1999]

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