IUBMB Enzyme Nomenclature


Accepted name: (S)-limonene 3-monooxygenase

Reaction: (S)-limonene + NADPH + H+ + O2 = trans-isopiperitenol + NADP+ + H2O

For diagram click here.

limonene: a monoterpenoid
(S)-limonene = (–)-limonene

Other name(s): (–)-limonene 3-hydroxylase; (–)-limonene 3-monooxygenase; (–)-limonene,NADPH:oxygen oxidoreductase (3-hydroxylating)

Systematic name: (S)-limonene,NADPH:oxygen oxidoreductase (3-hydroxylating)

Comments: High specificity, but NADH can act instead of NADPH, although more slowly. A heme-thiolate protein (P-450).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, UM-BBD, CAS registry number: 138066-92-9


1. Karp, F., Mihaliak, C.A., Harris, J.L. and Croteau, R. Monoterpene biosynthesis: specificity of the hydroxylations of (–)-limonene by enzyme preparations from peppermint (Mentha piperita), spearmint (Mentha spicata), and perilla (Perilla frutescens) leaves. Arch. Biochem. Biophys. 276 (1990) 219-226. [PMID: 2297225]

[EC created 1992, modified 2003]

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