IUBMB Enzyme Nomenclature


Accepted name: methyltetrahydroprotoberberine 14-monooxygenase

Reaction: (S)-N-methylcanadine + NADPH + H+ + O2 = allocryptopine + NADP+ + H2O

For diagram click here.

Other name(s): methyltetrahydroprotoberberine 14-hydroxylase; (S)-cis-N-methyltetrahydroberberine 14-monooxygenase; (S)-cis-N-methyltetrahydroprotoberberine-14-hydroxylase

Systematic name: (S)-N-methylcanadine,NADPH:oxygen oxidoreductase (14-hydroxylating)

Comments: A heme-thiolate protein (P-450).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 113478-42-5


1. Rueffer, M. and Zenk, M.H. Enzymatic formation of protopines by a microsomal cytochrome-P-450 system of Corydalis vaginans. Tetrahedron Lett. 28 (1987) 5307-5310.

[EC created 1990]

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