IUBMB Enzyme Nomenclature

EC 1.14.13.213

Accepted name: bursehernin 5'-monooxygenase

Reaction: (–)-bursehernin + NADPH + H+ + O2 = (–)-5'-demethylyatein + NADP+ + H2O

Glossary: (–)-bursehernin = (3R,4R)-4-(2H-1,3-benzodioxol-5-ylmethyl)-3-[(3,4-dimethoxyphenyl)methyl]oxolan-2-one
(-)-5'-demethylyatein = (3R,4R)-4-(2H-1,3-benzodioxol-5-ylmethyl)-3-[(3-hydroxy-4,5-dimethoxyphenyl)methyl]oxolan-2-one
(-)-yaetin = (3R,4R)-4-(2H-1,3-benzodioxol-5-ylmethyl)-3-[(3,4,5-trimethoxyphenyl)methyl]oxolan-2-one

Other name(s): CYP71CU1 (gene name); bursehernin 5'-hydroxylase

Systematic name: (-)-bursehernin,NADPH:oxygen oxidoreductase (5'-hydroxylating)

Comments: This cytochrome P450 enzyme, characterized from the plant Sinopodophyllum hexandrum, is involved in the biosynthetic pathway of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:

References:

1. Lau, W. and Sattely, E.S. Six enzymes from mayapple that complete the biosynthetic pathway to the etoposide aglycone. Science 349 (2015) 1224-1228. [PMID: 26359402]

[EC 1.14.13.213 created 2016]


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