IUBMB Enzyme Nomenclature

EC 1.14.13.206

Accepted name: laurate 7-monooxygenase

Reaction: dodecanoate + NADPH + H+ + O2 = 7-hydroxydodecanoate + NADP+ + H2O

Glossary: laurate = dodecanoate

Other name(s): CYP703A2

Systematic name: dodecanoate,NADPH:oxygen oxidoreductase (7-hydroxylating)

Comments: This plant enzyme is involved in the synthesis of sporopollenin - a complex polymer found at the outer layer of spores and pollen. It can also act on decanoate (C10), myristate (C14), and palmitate (C16) with lower activity. The enzyme also produces a small amount of products that are hydroxylated at neighboring positions (C-6, C-8 and C-9).

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:

References:

1. Morant, M., Jørgensen, K., Schaller, H., Pinot, F., Møller, B.L., Werck-Reichhart, D. and Bak, S. CYP703 is an ancient cytochrome P450 in land plants catalyzing in-chain hydroxylation of lauric acid to provide building blocks for sporopollenin synthesis in pollen. Plant Cell 19 (2007) 1473-1487. [PMID: 17496121]

[EC 1.14.13.206 created 2015]


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