Reaction: dodecanoate + NADPH + H+ + O2 = 7-hydroxydodecanoate + NADP+ + H2O
Glossary: laurate = dodecanoate
Other name(s): CYP703A2
Systematic name: dodecanoate,NADPH:oxygen oxidoreductase (7-hydroxylating)
Comments: This plant enzyme is involved in the synthesis of sporopollenin - a complex polymer found at the outer layer of spores and pollen. It can also act on decanoate (C10), myristate (C14), and palmitate (C16) with lower activity. The enzyme also produces a small amount of products that are hydroxylated at neighboring positions (C-6, C-8 and C-9).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
1. Morant, M., Jørgensen, K., Schaller, H., Pinot, F., Møller, B.L., Werck-Reichhart, D. and Bak, S. CYP703 is an ancient cytochrome P450 in land plants catalyzing in-chain hydroxylation of lauric acid to provide building blocks for sporopollenin synthesis in pollen. Plant Cell 19 (2007) 1473-1487. [PMID: 17496121]