Reaction: (1) oleoyl-CoA + NADPH + H+ + O2 = 18-hydroxyoleoyl-CoA + NADP+ + H2O
(2) linoleoyl-CoA + NADPH + H+ + O2 = 18-hydroxylinoleoyl-CoA + NADP+ + H2O
Other name(s): long-chain acyl-CoA ω-hydroxylase; CYP86A22 (gene name); CYP52M1 (gene name)
Systematic name: long-chain acyl-CoA,NADPH:oxygen oxidoreductase (ω-hydroxylating)
Comments: The enzymes from solanaceous plants are involved in the biosynthesis of stigmatic estolide, a lipid-based polyester that forms a major component of the exudate.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
1. Han, J., Clement, J.M., Li, J., King, A., Ng, S. and Jaworski, J.G. The cytochrome P450 CYP86A22 is a fatty acyl-CoA ω-hydroxylase essential for estolide synthesis in the stigma of Petunia hybrida. J. Biol. Chem. 285 (2010) 3986-3996. [PMID: 19940120]