Reaction: methyl (2E,6E)-farnesoate + NADPH + H+ + O2 = juvenile hormone III + NADP+ + H2O
For diagram of reaction click here.
Glossary: juvenile hormone III = methyl (2E,6E,10R)-10,11-epoxy-3,7,11-trimethyldodeca-2,6-dienoate
Other name(s): CYP15A1
Systematic name: methyl (2E,6E)-farnesoate,NADPH:oxygen oxidoreductase
Comments: A heme-thiolate protein (cytochrome P-450). The enzyme, found in insects except for Lepidoptera (moths and butterflies) is specific for methyl farnesoate (cf. EC 126.96.36.199, farnesoate epoxidase) [1,2].
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
1. Helvig, C., Koener, J.F., Unnithan, G.C. and Feyereisen, R. CYP15A1, the cytochrome P450 that catalyzes epoxidation of methyl farnesoate to juvenile hormone III in cockroach corpora allata. Proc. Natl. Acad. Sci. USA 101 (2004) 4024-4029. [PMID: 15024118]
2. Daimon, T. and Shinoda, T. Function, diversity, and application of insect juvenile hormone epoxidases (CYP15). Biotechnol. Appl. Biochem. 60 (2013) 82-91. [PMID: 23586995]