IUBMB Enzyme Nomenclature

EC 1.14.13.177

Accepted name: fumitremorgin C monooxygenase

Reaction: fumitremorgin C + 2 NADPH + 2 H+ + 2 O2 = 12α,13α-dihydroxyfumitremorgin C + 2 NADP+ + 2 H2O

For diagram of reaction click here.

Glossary: fumitremorgin C = (5aS,12S,14aS)-9-methoxy-12-(2-methylprop-1-en-1-yl)-1,2,3,5a,6,11,12,14a-octahydro-5H,14H-pyrrolo[1'',2'':4',5']pyrazino[1',2':1,6]pyrido[3,4-b]indole-5,14-dione
12α,13α-dihydroxyfumitremorgin = (5aR,6S,12S,14aS)-5a,6-dihydroxy-9-methoxy-12-(2-methylprop-1-en-1-yl)-1,2,3,5a,6,11,12,14a-octahydro-5H,14H-pyrrolo[1'',2'':4',5']pyrazino[1',2':1,6]pyrido[3,4-b]indole-5,14-dione

Other name(s): ftmG (gene name)

Systematic name: fumitremorgin C,NADPH:oxygen oxidoreductase (12α,13α-dihydroxyfumitremorgin C-forming)

Comments: A heme-thiolate protein (P-450). Involved in the biosynthetic pathway of the indole alkaloid verruculogen.

Links to other databases: BRENDA, EXPASY, KEGG Metacyc, CAS registry number:

References:

1. Kato, N., Suzuki, H., Takagi, H., Asami, Y., Kakeya, H., Uramoto, M., Usui, T., Takahashi, S., Sugimoto, Y. and Osada, H. Identification of cytochrome P450s required for fumitremorgin biosynthesis in Aspergillus fumigatus. ChemBioChem. 10 (2009) 920-928. [PMID: 19226505]

[EC 1.14.13.177 created 2013]


Return to EC 1.14.13 home page
Return to EC 1.14 home page
Return to EC 1 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page