IUBMB Enzyme Nomenclature

EC 1.14.13.174

Accepted name: averantin hydroxylase

Reaction: (1) (1'S)-averantin + NADPH + H+ + O2 = (1'S,5'S)-5'-hydroxyaverantin + NADP+ + H2O
(2) (1'S)-averantin + NADPH + H+ + O2 = (1'S,5'R)-5'-hydroxyaverantin + NADP+ + H2O

For diagram of reaction click here.

Glossary: averantin = 1,3,6,8-tetrahydroxy-2-[(1S)-1-hydroxyhexyl]anthracene-9,10-dione

Other name(s): AVN hydroxylase; avnA (gene name); (1'S)-averantin,NADPH:O2 oxidoreductase (5'-hydroxylating)

Systematic name: (1'S)-averantin,NADPH:oxygen oxidoreductase (5'-hydroxylating)

Comments: A heme-thiolate (P-450) monooxygenase isolated from Aspergillus parasiticus. There is no reaction with (1'R)-averantin. Involved in aflatoxin biosynthesis.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:

References:

1. Yabe, K., Matsuyama, Y., Ando, Y., Nakajima, H. and Hamasaki, T. Stereochemistry during aflatoxin biosynthesis: conversion of norsolorinic acid to averufin. Appl. Environ. Microbiol. 59 (1993) 2486-2492. [PMID: 8368836]

[EC 1.14.13.174 created 2013]


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