IUBMB Enzyme Nomenclature

EC 1.14.13.173

Accepted name: 11-oxo-β-amyrin 30-oxidase

Reaction: 11-oxo-β-amyrin + 3 O2 + 3 NADPH + 3 H+ = glycyrrhetinate + 3 NADP+ + 4 H2O (overall reaction)
(1a) 11-oxo-β-amyrin + O2 + NADPH + H+ = 30-hydroxy-11-oxo-β-amyrin + NADP+ + H2O
(1b) 30-hydroxy-11-oxo-β-amyrin + O2 + NADPH + H+ = glycyrrhetaldehyde + NADP+ + 2 H2O
(1c) glycyrrhetaldehyde + O2 + NADPH + H+ = glycyrrhetinate + NADP+ + H2O

For diagram of reaction click here.

Other name(s): CYP72A; CYP72A154

Systematic name: 11-oxo-β-amyrin,NADPH:oxygen oxidoreductase (30-hydroxylating)

Comments: A heme-thiolate protein (cytochrome P-450). The enzyme is involved in the biosynthesis of the triterpenoid saponin glycyrrhizin in the plant Glycyrrhiza uralensis (licorice). The enzyme from the plant Medicago truncatula can also hydroxylate β-amyrin.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:

References:

1. Seki, H., Sawai, S., Ohyama, K., Mizutani, M., Ohnishi, T., Sudo, H., Fukushima, E.O., Akashi, T., Aoki, T., Saito, K. and Muranaka, T. Triterpene functional genomics in licorice for identification of CYP72A154 involved in the biosynthesis of glycyrrhizin. Plant Cell 23 (2011) 4112-4123. [PMID: 22128119]

[EC 1.14.13.173 created 2013]


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