IUBMB Enzyme Nomenclature

EC 1.14.13.150

Accepted name: α-humulene 10-hydroxylase

Reaction: α-humulene + O2 + NADPH + H+ = 10-hydroxy-α-humulene + NADP+ + H2O

For diagram of reaction click here.

Other name(s): CYP71BA1

Systematic name: α-humulene,NADPH:oxygen 10-oxidoreductase

Comments: Requires cytochrome P450. The recommended numbering of humulene gives 10-hydroxy-α-humulene as the product rather than 8-hydroxy-α-humulene as used by the reference. See Section F: Natural Product Nomenclature.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:

References:

1. Yu, F., Okamoto, S., Harada, H., Yamasaki, K., Misawa, N. and Utsumi, R. Zingiber zerumbet CYP71BA1 catalyzes the conversion of α-humulene to 8-hydroxy-α-humulene in zerumbone biosynthesis. Cell. Mol. Life Sci. 68 (2011) 1033-1040. [PMID: 20730551]

[EC 1.14.13.150 created 2012]


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