IUBMB Enzyme Nomenclature

EC 1.14.13.147

Accepted name: taxoid 7β-hydroxylase

Reaction: taxusin + O2 + NADPH + H+ = 7β-hydroxytaxusin + NADP+ + H2O

Glossary: taxusin = taxa-4(20),11-diene-5α,9α,10β,13α-tetrayl tetraacetate

Systematic name: taxusin,NADPH:oxygen 7-oxidoreductase

Comments: Requires cytochrome P450. From the yew tree Taxus cuspidata. Does not act on earlier intermediates in taxol biosynthesis.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:

References:

1. Chau, M., Jennewein, S., Walker, K. and Croteau, R. Taxol biosynthesis: molecular cloning and characterization of a cytochrome P450 taxoid 7 β-hydroxylase. Chem. Biol. 11 (2004) 663-672. [PMID: 15157877]

[EC 1.14.13.147 created 2012]


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