IUBMB Enzyme Nomenclature

EC 1.14.13.144

Accepted name: 9β-pimara-7,15-diene oxidase

Reaction: 9β-pimara-7,15-diene + 3 O2 + 3 NADPH + 3 H+ = 9β-pimara-7,15-dien-19-oate + 3 NADP+ + 4 H2O (overall reaction)
(1a) 9β-pimara-7,15-diene + O2 + NADPH + H+ = 9β-pimara-7,15-dien-19-ol + NADP+ + H2O
(1b) 9β-pimara-7,15-dien-19-ol + O2 + NADPH + H+ = 9β-pimara-7,15-dien-19-al + NADP+ + 2 H2O
(1c) 9β-pimara-7,15-dien-19-al + O2 + NADPH + H+ = 9β-pimara-7,15-dien-19-oate + NADP+ + H2O

For diagram of reaction click here.

Glossary: syn-pimara-7,15-diene = 9β-pimara-7,15-diene

Other name(s): CYP99A3

Systematic name: 9β-pimara-7,15-diene,NADPH:oxygen 19-oxidoreductase

Comments: Requires cytochrome P450. A rice, Oryza sativa, enzyme involved in the phytoalexin momilactone biosynthesis. It also acts similarly on 9β-stemod-13(17)-ene.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:

References:

1. Wang, Q., Hillwig, M.L. and Peters, R.J. CYP99A3: functional identification of a diterpene oxidase from the momilactone biosynthetic gene cluster in rice. Plant J. 65 (2011) 87-95. [PMID: 21175892]

[EC 1.14.13.144 created 2012]


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