Reaction: ent-isokaurene + O2 + NADPH + H+ = ent-2α-hydroxyisokaurene + H2O + NADP+
For diagram of reaction click here.
Other name(s): CYP71Z6
Systematic name: ent-isokaurene,NADPH:oxygen oxidoreductase (hydroxylating)
Comments: This is the initial step in the conversion of ent-isokaurene to the antibacterial oryzalides in rice, Oryza sativa.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
1. Wu, Y., Hillwig, M.L., Wang, Q. and Peters, R.J. Parsing a multifunctional biosynthetic gene cluster from rice: biochemical characterization of CYP71Z6 & 7. FEBS Lett. 585 (2011) 3446-3451. [PMID: 21985968]