IUBMB Enzyme Nomenclature


Accepted name: indole-2-monooxygenase

Reaction: indole + NAD(P)H + H+ + O2 = indolin-2-one + NAD(P)+ + H2O

For diagram of reaction click here.

Other name(s): BX2 (gene name); CYP71C4 (gene name)

Systematic name: indole,NAD(P)H:oxygen oxidoreductase (2-hydroxylating)

Comments: The enzyme is involved in the biosynthesis of protective and allelophatic benzoxazinoids in some plants, most commonly from the family of Poaceae (grasses). It is a member of the cytochrome P450 dependent monooxygenases.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Frey, M., Chomet, P., Glawischnig, E., Stettner, C., Grün, S., Winklmair, A., Eisenreich, W., Bacher, A., Meeley, R.B., Briggs, S.P., Simcox, K. and Gierl, A. Analysis of a chemical plant defense mechanism in grasses. Science 277 (1997) 696-699. [PMID: 9235894]

2. Glawischnig, E., Grun, S., Frey, M. and Gierl, A. Cytochrome P450 monooxygenases of DIBOA biosynthesis: specificity and conservation among grasses. Phytochemistry 50 (1999) 925-930. [PMID: 10385992]

[EC created 2012]

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