IUBMB Enzyme Nomenclature

EC 1.14.13.134

Accepted name: β-amyrin 11-oxidase

Reaction: β-amyrin + 2 O2 + 2 NADPH + 2 H+ = 11-oxo-β-amyrin + 3 H2O + 2 NADP+ (overall reaction)
(1a) β-amyrin + O2 + NADPH + H+ = 11α-hydroxy-β-amyrin + H2O + NADP+
(1b) 11α-hydroxy-β-amyrin + O2 + NADPH + H+ = 11-oxo-β-amyrin + 2 H2O + NADP+

For diagram of reaction click here.

Other name(s): CYP88D6

Systematic name: β-amyrin,NADPH:oxygen oxidoreductase (hydroxylating)

Comments: Requires cytochrome P450. Part of the glycyrrhizin biosynthesis pathway. The enzyme is also able to oxidize 30-hydroxy-β-amyrin to 11α,30-dihydroxy-β-amyrin but this is not thought to be part of glycyrrhizin biosynthesis.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:

References:

1. Seki, H., Ohyama, K., Sawai, S., Mizutani, M., Ohnishi, T., Sudo, H., Akashi, T., Aoki, T., Saito, K. and Muranaka, T. Licorice β-amyrin 11-oxidase, a cytochrome P450 with a key role in the biosynthesis of the triterpene sweetener glycyrrhizin. Proc. Natl. Acad. Sci. USA 105 (2008) 14204-14209. [PMID: 18779566]

[EC 1.14.13.134 created 2011]


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