IUBMB Enzyme Nomenclature


Accepted name: pentalenene oxygenase

Reaction: pentalenene + 2 NADPH + 2 H+ + 2 O2 = pentalen-13-al + 2 NADP+ + 3 H2O (overall reaction)
(1a) pentalenene + NADPH + H+ + O2 = pentalen-13-ol + NADP+ + H2O
(1b) pentalen-13-ol + NADPH + H+ + O2 = pentalen-13-al + NADP+ + 2 H2O

For diagram of reaction click here.

Other name(s): PtlI

Systematic name: pentalenene,NADPH:oxygen 13-oxidoreductase

Comments: A heme-thiolate protein (P-450). The enzyme is involved in the biosynthesis of pentalenolactone and related antibiotics.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Quaderer, R., Omura, S., Ikeda, H. and Cane, D.E. Pentalenolactone biosynthesis. Molecular cloning and assignment of biochemical function to PtlI, a cytochrome P450 of Streptomyces avermitilis. J. Am. Chem. Soc. 128 (2006) 13036-13037. [PMID: 17017767]

[EC created 2011]

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