IUBMB Enzyme Nomenclature

EC 1.14.12.5

Accepted name: 5-pyridoxate dioxygenase

Reaction: 3-hydroxy-4-hydroxymethyl-2-methylpyridine-5-carboxylate + NADPH + H+ + O2 = 2-(acetamidomethylene)-3-(hydroxymethyl)succinate + NADP+

Other name(s): 5-pyridoxate oxidase; 5-pyridoxate,NADPH:oxygen oxidoreductase (decyclizing)

Systematic name: 5-pyridoxate,NADPH:oxygen oxidoreductase (ring-opening)

Comments: A flavoprotein.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, UM-BBD, CAS registry number: 37256-70-5

References:

1. Sparrow, L.G., Ho, P.P.K., Sundaram, T.K., Zach, D., Nyns, E.J. and Snell, E.E. The bacterial oxidation of vitamin B6. VII. Purification, properties, and mechanism of action of an oxygenase which cleaves the 3-hydroxypyridine ring. J. Biol. Chem. 244 (1969) 2590-2600. [PMID: 4306031]

[EC 1.14.12.5 created 1972]


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