Reaction: 31-hydroxy-L-isoleucine + 2-oxoglutarate + O2 = (4S)-31,4-dihydroxy-L-isoleucine + succinate + CO2
Other name(s): hilB (gene name); 4'-hydroxy-L-isoleucine 4-dioxygenase (incorrect)
Systematic name: 31-hydroxy-L-isoleucine, 2-oxoglutarate:oxygen oxidoreductase (4S-hydroxylating)
Comments: Requires Fe2+ and ascorbate. The enzyme has been characterized from the bacterium Pantoea ananatis.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Smirnov, S.V., Sokolov, P.M., Kotlyarova, V.A., Samsonova, N.N., Kodera, T., Sugiyama, M., Torii, T., Hibi, M., Shimizu, S., Yokozeki, K. and Ogawa, J. A novel L-isoleucine-4'-dioxygenase and L-isoleucine dihydroxylation cascade in Pantoea ananatis. MicrobiologyOpen 2 (2013) 471-481. [PMID: 23554367]