IUBMB Enzyme Nomenclature


Accepted name: procollagen-proline 3-dioxygenase

Reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-3-hydroxy-L-proline + succinate + CO2

For diagram click here.

Other name(s): proline,2-oxoglutarate 3-dioxygenase; prolyl 3-hydroxylase; protocollagen proline 3-hydroxylase; prolyl-4-hydroxyprolyl-glycyl-peptide, 2-oxoglutarate: oxygen oxidoreductase, 3-hydroxylating

Systematic name: procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)

Comments: Requires Fe2+ and ascorbate.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 63551-75-7


1. Risteli, J., Tryggvason, K. and Kivirikko, K.I. Prolyl 3-hydroxylase: partial characterization of the enzyme from rat kidney cortex. Eur. J. Biochem. 73 (1977) 485-492. [PMID: 191255]

2. Risteli, J., Tryggvason, K. and Kivirikko, K.I. A rapid assay for prolyl 3-hydroxylase activity. Anal. Biochem. 84 (1978) 423-431. [PMID: 204218]

[EC created 1981, modified 1983]

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