IUBMB Enzyme Nomenclature

EC 1.14.11.56

Accepted name: L-proline cis-4-hydroxylase

Reaction: L-proline + 2-oxoglutarate + O2 = cis-4-hydroxy-L-proline + succinate + CO2

Systematic name: L-proline,2-oxoglutarate:oxygen oxidoreductase (cis-4-hydroxylating)

Comments: Requires Fe2+ and ascorbate. The enzyme, isolated from Rhizobium species, only produces cis-4-hydroxy-L-proline (cf. EC 1.14.11.57, L-proline trans-4-hydroxylase).

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:

References:

1. Hara, R. and Kino, K. Characterization of novel 2-oxoglutarate dependent dioxygenases converting L-proline to cis-4-hydroxy-L-proline. Biochem. Biophys. Res. Commun. 379 (2009) 882-886. [PMID: 19133227]

[EC 1.14.11.56 created 2017]


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