IUBMB Enzyme Nomenclature

EC 1.14.11.10

Accepted name: pyrimidine-deoxynucleoside 1'-dioxygenase

Reaction: 2'-deoxyuridine + 2-oxoglutarate + O2 = uracil + 2-deoxyribonolactone + succinate + CO2

Other name(s): deoxyuridine-uridine 1'-dioxygenase

Systematic name: 2'-deoxyuridine,2-oxoglutarate:oxygen oxidoreductase (1'-hydroxylating)

Comments: Requires Fe(II) and ascorbate. cf. EC 1.14.11.3, pyrimidine-deoxynucleoside 2'-dioxygenase.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 98865-52-2

References:

1. Stubbe, J. Identification of two α-ketoglutarate-dependent dioxygenases in extracts of Rhodotorula glutinis catalyzing deoxyuridine hydroxylation. J. Biol. Chem. 260 (1985) 9972-9975. [PMID: 4040518]

[EC 1.14.11.10 created 1989, modified 2002]


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