IUBMB Enzyme Nomenclature

EC 1.13.11.4

Accepted name: gentisate 1,2-dioxygenase

Reaction: 2,5-dihydroxybenzoate + O2 = maleylpyruvate

Other name(s): gentisate oxygenase; 2,5-dihydroxybenzoate dioxygenase; gentisate dioxygenase; gentisic acid oxidase

Systematic name: gentisate:oxygen 1,2-oxidoreductase (decyclizing)

Comments: Requires Fe2+.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9029-48-5

References:

1. Hayaishi, O. Direct oxygenation by O2, oxygenases. In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds.), The Enzymes, 2nd ed., vol. 8, Academic Press, New York, 1963, p. 353-371.

2. Sugiyama, S., Yano, K., Komagata, K. and Arima, K. Metabolites of aromatic compounds by microbes. Part VII. Gentisic acid oxidase. Bull. Agric. Chem. Soc. Jpn 24 (1960) 243-248.

3. Sugiyama, S., Yano, K. and Arima, K. Metabolites of aromatic compounds by microbes. Part VII. Further studies of gentisic acid oxidase. Bull. Agric. Chem. Soc. Jpn 24 (1960) 249-254.

[EC 1.13.11.4 created 1961 as EC 1.99.2.4, transferred 1965 to EC 1.13.1.4, transferred 1972 to EC 1.13.11.4]


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