Reaction: (R)-lactaldehyde + NAD+ = methylglyoxal + NADH + H+
Glossary: methylglyoxal = 2-oxopropanal
Other name(s): methylglyoxal reductase; D-lactaldehyde dehydrogenase; methylglyoxal reductase (NADH-dependent)
Systematic name: (R)-lactaldehyde:NAD+ oxidoreductase
Comments: This mammalian enzyme differs from the yeast enzyme, EC 188.8.131.523, methylglyoxal reductase (NADPH-dependent), in preferring NADH over NADPH as reductant.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 37250-16-1
1. Ting, S.-M., Miller, O.N. and Sellinger, O.Z. The metabolism of lactaldehyde. VII. The oxidation of D-lactaldehyde in rat liver. Biochim. Biophys. Acta 97 (1965) 407-415. [PMID: 14323585]
2. Ray, M. and Ray, S. Purification and partial characterization of a methylglyoxal reductase from goat liver. Biochim. Biophys. Acta 802 (1984) 119-127. [PMID: 6386056]