IUBMB Enzyme Nomenclature


Accepted name: malate dehydrogenase (decarboxylating)

Reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH

Other name(s): 'malic' enzyme; pyruvic-malic carboxylase; NAD-specific malic enzyme; NAD-malic enzyme

Systematic name: (S)-malate:NAD+ oxidoreductase (decarboxylating)

Comments: Does not decarboxylate added oxaloacetate.

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9028-46-0


1. Saz, H.J. and Hubbard, J.A. The oxidative decarboxylation of malate by Ascaris lumbricoides. J. Biol. Chem. 225 (1957) 921-933.

[EC created 1961]

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