Reaction: 3α-hydroxyglycyrrhetinate + NADP+ = 3-oxoglycyrrhetinate + NADPH + H+
Systematic name: 3α-hydroxyglycyrrhetinate:NADP+ 3-oxidoreductase
Comments: Highly specific to 3α-hydroxy derivatives of glycyrrhetinate and its analogues. Not identical to EC 220.127.116.11 3α-hydroxysteroid dehydrogenase (Si-specific).
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 114308-07-5
1. Akao, T., Akao, T., Hattori, M., Namba, T. and Kobashi, K. Purification and properties of 3α-hydroxyglycyrrhetinate dehydrogenase of Clostridium innocuum from human intestine. J. Biochem. (Tokyo) 103 (1988) 504-507. [PMID: 3164718]