Reaction: GDP-D-mannose + 2 NAD+ + H2O = GDP-D-mannuronate + 2 NADH + 2 H+
Other name(s): guanosine diphosphomannose dehydrogenase; GDP mannose dehydrogenase; guanosine diphosphomannose dehydrogenase; guanosine diphospho-D-mannose dehydrogenase
Systematic name: GDP-D-mannose:NAD+ 6-oxidoreductase
Comments: Also acts on the corresponding deoxynucleoside diphosphate derivative as a substrate.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 37250-63-8
References:
1. Preiss, J. Sugar nucleotide reaction in Arthrobacter. II. Biosynthesis of guanosine diphosphomannuronate. J. Biol. Chem. 239 (1964) 3127-3132.